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Editorial note: No randomized controlled trial has yet tested resistance training as a counter-measure specifically to GLP-1-induced lean-mass loss

Semaglutide and liraglutide are structurally similar molecules with high selectivity for the GLP-1 receptor, though there are some pharmacologic differences between the two notably, liraglutide has a higher steady state concentration and greater receptor binding affinity than semaglutide, while semaglutide has an increased affinity for serum albumin (thereby improving resistance to degradation) and a longer half-life than liraglutide [38, 61, 62]

The letter should also provide supporting evidence, such as medical records and relevant test results, to strengthen the case for coverage approval

It is intended for daily use with a strong safety profile and minimal reported side effects when used as directed