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Common autoimmune conditions linked to chronic fatigue include: Hashimotos thyroiditis which causes a sluggish metabolism and energy loss Rheumatoid arthritis where systemic inflammation leads to exhaustion Lupus with widespread inflammation, mitochondrial dysfunction and fatigue Multiple sclerosis which damages nerves and affects energy levels Sjogrens syndrome presenting with dry eyes and mouth as well as fatigue How autoimmune activity triggers fatigue: The immune system releases inflammatory molecules called cytokines which interfere with cellular energy production Autoimmune diseases are linked to mitochondrial dysfunction, where the cells powerhouses fail to generate enough energy Conditions like leaky gut, dysbiosis (imbalanced gut bacteria), and food sensitivitiescommon in autoimmune diseasescontribute to fatigue by promoting systemic inflammation Could Your Fatigue Be Autoimmune-Related

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Neither agent individually holds MHRA marketing authorisation, and both remain in clinical development

Abstract Drug-induced liver injury (DILI) is a serious health burden