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Stimulation of IGFBP-2 expression by HOTAIR appears to mediate this effect, since enhanced cell migration and tumor growth in vivo resulting from HOTAIR overexpression was reversed by IGFBP-2 silencing [48]

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For the group of hypothyroid patients with precipitating causes, like autoimmune disease, immunosuppressive treatment, or handling of the autoimmune response might also be implemented along with thyroid hormone replacement (Men et al