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276,277 Further investigation demonstrated that miR-181a-5p enveloped in MSC-EVs could upregulate pSTAT5 and SOCS1 expression in alveolar macrophages, exerting anti-inflammatory and immunomodulatory effects in the context of ARDS

However, although the metabolic efficacy of these emerging agents is clear, their long-term cardiovascular safety profiles remain speculative until the conclusion of ongoing phase 3 trials (Wharton et al., 2025)

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70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well