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The multi-pathway approach is what I find most compelling about BPC-157

h , Uptake of [ 3 H]GSH after incubation with 400 M unlabelled GSH and 4 M [ 3 H]GSH into ER at indicated times

3.1.1 Follicular fluid EVs regulate ovarian granulosa cells and cumulus cells, affecting follicle development Ovarian granulosa cells are essential for follicle development, forming the follicular wall around the oocyte and facilitating nutrient delivery to support oocyte growth and maturation, thereby ameliorating ovulation disorders ( In polycystic ovary syndrome (PCOS) patients, follicular fluid EVs are enriched in S100-A9, which promotes inflammation and disrupts steroidogenesis by activating the NF-B pathway, thereby impairing granulosa cell function ( via the CDCA4-mediated Rb/E2F1 pathway (Yuan et al., 2021)

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