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The accepted definition of sleep disturbances on the basis of actigraphic sleep/awake study is of sleep efficiency of less then 90% and/or three or more awakenings on a nightly average (28)

Most people remain on the starting dose of 2mg throughout these weeks

Santini F, Marzullo P, Rotondi M, Ceccarini G, Pagano L, Ippolito S et al (2014) Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

The fragment library for the vBrood application was prepared using the CHOMP application to fragment the ChEMBL database 77 version CHEMBL25 78

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