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Bapat SP, Myoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y

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( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels (73)

Scenario Weekly Units Vial Duration Loading (10 units 5/wk) 50 units ~4 weeks per vial Full 12-week cycle Variable ~23 vials Storage and Stability Store the reconstituted KLOW vial refrigerated at 28C and use it within approximately 28 days of reconstitution, consistent with the bacteriostatic preservation window