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26 As the disease progresses, cells are no longer able to secrete enough insulin to compensate for the abnormally high blood glucose, leading to progression to prediabetes or T2D

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10.1111/j.1469-7793.2001.0283f.x J Physiol

94 Experimental and clinical research has substantiated that elevated uric acid levels exert detrimental effects on cardiovascular health, with increased oxidative stress being a key mechanism implicated in these adverse outcomes, 6,66 decreased nitric oxide availability, endothelial dysfunction, the promotion of local and systemic inflammation, vasoconstriction, vascular smooth muscle cell proliferation, insulin resistance 309 and metabolic disorder