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10.1371/journal.pone.0069010 16 Eren-YaziciogluC

L-arginine provides an immediate boost to nitric oxide production, while L-citrulline creates a sustained release that extends the benefits over a longer period

Since storage additives are devoid of amino acids, elevation in intracellular amino acids is consistent with proteolysis (e.g., via proteasomal degradation), a phenomenon that is mechanistically linked to (extravascular) hemolysis 45

Several factors can reduce glutathione levels in the body, including: Chronic stress Poor nutrition Smoking Excessive alcohol consumption Lack of sleep Environmental pollution Aging Certain medical conditions Managing these factors may help support healthy glutathione levels over time