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which reported a heightened risk of thyroid cancer, particularly medullary thyroid cancer, associated with other GLP-1 RAs such as liraglutide and exenatide [133]

GLP-1 receptor agonists mimic the action of naturally occurring hormones that regulate blood glucose and appetite by: Slowing gastric emptying, promoting feelings of fullness Reducing appetite signals in the brains hunger centers Improving insulin secretion while suppressing glucagon release Creating a caloric deficit through reduced food intake Originally developed for type 2 diabetes management, these medications have gained FDA approval for chronic weight management in adults with obesity or overweight with weight-related comorbidities

Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis

Lauer AA, Grimm HS, Apel B, Golobrodska N, Kruse L, Ratanski E, et al