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These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88

These more severe complications include gallbladder disease, kidney disease, allergic reactions, pancreatitis, and thyroid cancer

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These hepatic improvements, which may be associated with cotadutide's glucagon activity, indicate its potential as a therapeutic option for nonalcoholic steatohepatitis (NASH)