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Description

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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ClinicalTrials.gov A Study of Retatrutide (LY3437943) Once Weekly in Participants With Obesity and Knee Osteoarthritis (TRIUMPH-4)

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No effects were seen when glucose was not administered, compatible with the idea that DPP-4 inhibition exerts an anti-hyperglycaemic effect by preventing degradation of endogenously released GLP-1 (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)

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