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Worth noting that this is a practice observation, not a controlled clinical trial

Cuprizone autoimmune encephalitis (CAE) A variation of EAE where subdemyelinating doses of cuprizone are administered to mice (without exogenous myelin antigens), followed by an immune stimulation

(2025) demonstrated that well-designed public open spaces near railway stations in Greater Metropolitan Sydney can enable older adults to engage in physical activities and social interactions beyond their immediate residential neighbourhoods, potentially enhancing the physical, emotional and mental health

The result is a stronger collagen stimulus with a faster and calmer recovery than either intervention produces independently