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Additionally, ROS can upregulate HIF-1 expression, leading to activation of the Janus kinase (JAK) 2/STAT3 pathway, which promotes high RANKL expression and induces osteoclast differentiation (227)

Robert Ashley, MD, is an internist and assistant professor of medicine at the University of California, Los Angeles

Anti-IRS-1 rabbit polyclonal antibody, anti-phospho-STAT3 (Tyr705) rabbit monoclonal antibody and anti-STAT3 rabbit polyclonal antibody were obtained from Cell Signaling Technology

These events may lead to the synthesis of new collagen, thereby possibly contributing to tissue repair and regeneration mechanisms