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(GoodRx Semaglutide Side Effects) Drink plenty of fluids throughout the day aim for at least 6 to 8 glasses of water Avoid alcohol, which makes dehydration worse Take standard over-the-counter painkillers (paracetamol is a good first choice) ask your pharmacist for advice Rest in a cool, quiet room if the headache is severe Tiredness and Fatigue Feeling more tired than usual, especially early in treatment, is common

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Start your intake What Happens in the First Week of Semaglutide During the initial 7 days, semaglutide begins binding to GLP-1 receptors in your brain and gut, triggering early satiety signals