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Also, any continuous-release device must ensure the peptide does not stick to the matrix or container in a way that slows release too much or triggers aggregation, which could both impede release and increase immunogenicity

Severe hypoglycemia can lead to confusion, irritability, anxiety, and other mood disturbances

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[1] [28] [123] Other potential physical side effects include appetite loss, blurred vision, dry mouth, excessive grinding of the teeth, nosebleed, profuse sweating, rhinitis medicamentosa (drug-induced nasal congestion), reduced seizure threshold, tics (a type of movement disorder), and weight loss