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Ms all de la va de cAMP cannica, la activacin de GLP-1R por tirzepatide ha sido asociada con el reclutamiento de andamios -arrestina y dinmicas de internalizacin que difieren de las de agonistas selectivos de GLP-1R, ofreciendo una dimensin mecanicista relevante para la investigacin de la desensibilizacin de receptores y el agonismo sesgado

171 The development of small molecule GLP-1RAs aims to overcome some of the limitations of traditional protein or peptide-based GLP-1RAs, such as the need for injection