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John Horton: Yeah, it sounds like you need to put a stop to that pretty quickly or make some adjustments

The science behind semaglutide weight loss is robust, with extensive clinical trials demonstrating average weight loss of 15-20% of total body weight when combined with lifestyle modifications

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide cardiovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited

however, prolonged exercise increases the risk of hypoglycemia unless there is a decrease in circulating exogenous insulin levels (also known as insulin on board (IOB)) and/or carbohydrate intake (34)