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For context, semaglutide typically produces 15-17% weight reduction over similar timeframes, and tirzepatide achieves roughly 20-22%

Always follow the exact dose instructions provided by your care team

In the United Kingdom, they are approved for weight management when combined with a reduced calorie diet and physical activity for people with obesity or for those who are overweight with related health issues

The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform