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Metabolic roles of AMPK and metformin in cancer cells
Consequently, activation of these cascades leads to a reduction of the pro-inflammatory cytokine release, including tumor necrosis factor alpha (TNF-), interleukin 6 (IL-6), IL-1, Il-17, IL-2, and interferon (INF-), the so called non-T helper cells 2 (Th2)-mediated cytokine profile (Figure 2), and reduction in adhesion molecule release including vascular cell adhesion protein 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and E-selectin
The results showed that the formulation was well-tolerated, with no significant changes noted in tear film break-up time (TBUT), ocular surface staining, or ocular surface disease index (OSDI) ratings between the two regimens and associated with improvements in patients with moderate DED [100]