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In clinical trials of the oral Wegovy (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%17% over ~64 weeks compared with ~2% with placebo

Moving from mechanistic observations to clinical implementation will require a structured translational roadmap: Methodological Standardization: Standardizing microbiome sampling, sequencing platforms (transitioning from 16S rRNA to high-resolution shotgun metagenomics), and bioinformatic pipelines to improve reproducibility across international cohorts

Stool form scale as a useful guide to intestinal transit time

doi: 10.1073/pnas.90.20.9649 219 SchneiderW