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Its primary domain is inside the mitochondria, the microscopic powerhouses responsible for generating adenosine triphosphate (ATP), which is the energy currency of the cell

JAMA Intern Med 173(13):12221228 Liu XT, Hu J (2002Jun 15) Relationship between bilirubin free radical and formation of pigment gallstone

[PubMed: 29559356] (A 22 year old woman took an overdose of ALA [18,000 mg] and was found to be confused with severe metabolic acidosis [pH 7.22, lactate 76 mg/dL, ALT 11 U/L, AST 19 U/L, platelets 209,000 falling to 140,000/L], was treated with gastric lavage, charcoal administration and hydration and recovered within 3 days)

Conversely, for GPX, the most recent family to arise, only the cysteine-dependent subfamily GPX7 is conserved across metazoans, and common across Porifera