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Effects of Oral Semaglutide on Kidney Outcomes in People with Type 2 Diabetes: A Nationwide, Multicentre, Retrospective, Observational Study (Renal_ENDO2S-RWD substudy) In a real-world setting, oral semaglutide treatment for up to 52 weeks resulted in clinically meaningful reductions in albuminuria without changes in eGFR slope in PWT2D

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However, randomized clinical trials examining the efficacy of the medications for weight loss were not designed to capture rare gastrointestinal events due to their small sample sizes and short follow-up periods

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