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Ethical Approval SUSTAIN 6 and PIONEER 6 were approved by independent ethics committees and institutional review boards at each participating center and conducted in compliance with the International Conference on Harmonization Good Clinical Practice guidelines and the Declaration of Helsinki

Haematologica 1999;84(2):99102

It is a naturally occurring copper-binding tripeptide first isolated from human plasma, where its concentration declines markedly with age from roughly 200 ng/mL around age 20 to about 80 ng/mL by age 60, a decline that has been linked (correlationally) to the fall in regenerative capacity that accompanies aging