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Protein becomes critically important during GLP-1 therapy because rapid weight lossparticularly when exceeding 12 pounds per weekincreases the risk of losing muscle mass alongside fat tissue

Schoffelen, P

Higenamine: Higenamine is a beta-1 and beta-2 adrenergic agonist, meaning that it will stimulate the nervous system to boost metabolism and promote the break-down of subcutaneous adipose tissue (stubborn fat cells stored under skin)

This is a concerning complication where levels exceed safe ranges and potentially trigger adverse effects including acromegaly features, insulin resistance, carpal tunnel syndrome, and joint pain