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This metabolic cascade yields lipid oxidation products such as 4HNE and oxPLs [33, 34].Glutathione peroxidase 4 (GPX4), a pivotal antioxidant enzyme, functions as the core regulator of ferroptosis through the suppression of lipid peroxidation
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These insights are essential for understanding how the investigational compound behaves in humans and for informing future clinical development decisions
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