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The Anti-inflammatory Effects and Safety of PDA@Pt in Vivo The accumulation of MSU in joints and adjacent tissues activates tissue-resident macrophages, which phagocytose MSU, leading to the release of ROS and inflammatory mediators such as IL-1 and IL-6 [55]

Common with retinoids (e.g., tretinoin, retinal, retinol), AHAs/BHAs (glycolic, lactic, salicylic acid), vitamin C (rarely), and exfoliating enzymes (e.g., papain)

"Once they're gone, you can't regenerate pigment any more - the damage is permanent." In another experiment, the researchers found they could block the changes by giving the mice an anti-hypertensive, which treats high blood pressure