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Br J Pharmacol 141:311321 Hidalgo MA, Loncomn CA, Hidalgo AI, Andrade V, Carretta MD, Burgos RA (2014) Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period

This represents a significant limitation in the evidence base, as large-scale human trials examining musculoskeletal applications have not been published