Apart from this, the authors declare no conflict of interest
For example: Inborn Errors of Metabolism : Disorders like medium-chain acyl-CoA dehydrogenase deficiency (MCAD) result in the build-up of medium-chain acylcarnitines
The two primary MTHFR variants are C677T (rs1801133) which substitutes valine for alanine at position 222, reducing enzyme activity by approximately 35% in heterozygotes and 70% in T/T homozygotes at physiological folate concentrations and A1298C (rs1801131) which substitutes glutamate for alanine at position 429, reducing activity by approximately 20% in heterozygotes, with compound heterozygosity (C677T + A1298C) producing effects between the two individual homozygous states
Although rare, ION has recently been linked to GLP-1 receptor agonists, particularly semaglutide, marketed as Wegovy, Ozempic, and Rybelsus, and variously used to treat obesity, diabetes, and to reduce cardiovascular disease risk, according to a team of Canadian researchers from the universities of Ottawa, Calgary, and Toronto."Semaglutide, in any formulation, was the only agent significantly associated with ION, with the strongest signal for Wegovy, followed by Ozempic, the researchers said in the paper