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13 The latest meta-analysis shows that AN adult patients have an average reduction of 0.16 kg in whole-body bone mineral content, 14 and there is no gender difference in the reduction of BMD in adolescent patients, 15 In terms of bone microstructure, abnormalities are observed in the distal radius and distal tibia of AN patients, manifested as reduced volumetric bone mineral density (vBMD), decreased cortical bone area and thickness, increased porosity, decreased trabecular bone density and increased separation degree, but the results of studies on trabecular bone number changes are inconsistent

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Compounded tirzepatide remains not FDA-approved, and the post-shortage compounding landscape continues to tighten

TD oestrogen does not increase the risk of venous thromboembolism (VTE) and is therefore recommended for all women with an increased background risk of VTE, including a BMI 30 kg/m 2