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In a 12-week randomized clinical trial involving 300 obese adults, participants receiving 1 mg daily of AOD-9604 lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg (1.8 pounds) in the placebo group

71 These modulators can potentially provide more selective activation of the receptor, reducing adverse effects and improving efficacy

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Recent advancements in the field demonstrate the importance of modulating both melanocortin-3 and -4 receptors for optimal weight loss and offer solutions to mitigate undesired side effects associated with melanocortin agonism