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Some patients benefit from splitting the dose into two injections per week (e.g., Monday/Thursday) to reduce the peak-to-trough variation

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Clinical trials show that semaglutide produces dose-dependent weight loss, with higher maintenance doses (1.02.4 mg weekly) generating greater reductions than lower starting doses

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In addition, about 13% of those who took the drug had "altered skin sensation" such as tingling or extra sensitivity

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