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Acta Neuropsychiatrica, 32 , 218225

While Metal-X-Synergy is formulated to be a gentle alternative to harsh synthetic chelators, detoxification is a complex physiological process that should be approached with care, especially for those with Long COVID or ME/CFS whose systems are already highly sensitive

However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence

Most patients experience minimal downtime and can resume regular activities immediately