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Litvak et al., 2019)

This study found that melanocortin system activation results in unabated anorexia once the histaminergic neurons are silenced and suggests that, under normal conditions, the melanocortin-dependent activation of histaminergic neurons acts naturally as a negative feedback loop of the anorexigenic effects of the melanocortin system (147)

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This anchoring technique dramatically improves adherence without requiring willpower or complex tracking systems