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In rat experiments, a decrease in phylloquinone (vitamin K 1 ) and menaquinone-4 (a form of vitamin K 2 ) concentrations in extra-hepatic tissues was found in animals administered excess -tocopherol via the diet or by subcutaneous injection

EBioMedicine 98:104892

65 This protection is achieved through a variety of biological processes, including interactions with transition metals, neutralization of free radicals, modification of the activity of different enzymes, and impacts on intracellular signaling pathways and gene expression

INTRODUCTION Aging and growth of the world population, together with adoption of lifestyle factors such as smoking, obesogenic diets, and sedentary habits are escalating the global burden of cancer