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In some embodiments, the formulations or compositions described herein have a pH between about 3 and about 9, or between about 4 and 8, or between about 5 and 8, or between about 6 and about 7, or between about 6.5 and about 7, or between about 5.5 and about 7.5, or between about 7.1 and about 7.7, and have a concentration of active pharmaceutical ingredient between about 0.1 mM and about 100 mM

Others require the full 2.4 mg

Combination therapy and hybrid molecules that act through multiple receptors appear to maximize the beneficial outcomes, without increasing side effects of the single molecules