semaglutide pioneer Efficacy and safety of oral in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial Key efficacy outcomes of the

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The treatment normalized serum corticosterone levels, enhanced central GABA and serotonin concentrations and reduced peripheral inflammation and gut microbiota profiling revealed a reduction in potentially pathogenic genera ( Acinetobacter, Enterococcus, Bacillus ) and increased abundance of beneficial taxa ( Muribaculum, Alistipes, Lactobacillus ), indicating the therapeutic potential of targeted psychobiotic intervention for stress-related disorders (Tyagi et al., 2025)

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