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In preclinical research models, MOTS-C has been shown to translocate to the nucleus in response to metabolic stress, where it regulates the expression of antioxidant and metabolic response genes

"We don't really know why some people only lose 5% where some people are super responders and losing 30% of their body weight." Kushner thinks of the result as a kind of new settling point the medication helps establish, though why it lands so much lower for some people isn't well understood

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