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The gut microbiota dysbiosis promoted BA homeostasis disbalance, characterized by the accumulation of LCA and DCA in feces ( The alteration of BAs may also regulate the intestinal immune response ( via the smooth muscle cells present in the atheromatosus vessels of patients suffering from obesity-related NAFLD ( In conclusion, the current study demonstrates that HZRG treatment counteracts MCD-induced liver steatosis and inflammation, the beneficial effects of HZRG are associated with the modulation of gut dysbiosis and promotion of fecal BA excretion (Figure 7)

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