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It is to measure risk more accurately, think in cumulative exposure rather than 10-year probability, use apoB where standard markers are most likely to understate burden, intervene earlier when trajectory, family history, metabolic phenotype, or imaging warrant it, and keep treatment intensity proportional to both the evidence and the person in the consulting room

Plain sterile water does not contain this preservative and is appropriate only for single-use preparations

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The up-regulated p53-serine15 phosphorylation (p53-pS15) in keloids is identified by phosphospecific protein microarray and western blotting