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Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

The article says maintaining cold-chain handling from the moment of dispensing onward directly affects the medication's bioavailability and clinical effectiveness across the treatment month rather than merely shortening its usable life

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During Phase II, the body attaches (or "conjugates") specific molecules to the transformed toxins from Phase I