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As early as a few decades ago, it was shown that the glycocalyx covers the surface of most vascular lumens and that microcirculatory dysfunction and endothelial damage play important roles in the multiorgan failure associated with sepsis (53), and also that endothelial dysfunction and microcirculatory impairment are determinants of the severity and duration of sepsis (54)

We also observed significant changes in metabolites involved in important biological processes, including glycolysis, the TCA cycle, the pentose phosphate pathway, and amino acid metabolism (Fig