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PlexusDx compounded semaglutide injections are $189/mo month-to-month, or from $149/mo on the 6-month plan with no membership or insurance required

A separate and equally important counterpoint: a detailed 2026 evidence review published by Barbell Medicine found that GLP-1 medications do not appear to cause muscle loss beyond what matched caloric restriction produces on its own

Injectable GLP-1 has not been evaluated by the FDA, but side effects are expected to be similar to other GLP-1 based medications reviewed by the FDA, which have the following side effects: nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection), and gastroesophageal reflux disease (a type of digestive disorder)

Users often report smoother, younger-looking skin within 30 days