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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

Nierenberg, A

Receptor selectivity is important because it reduces endocrine cross-activation and minimizes confounding hormonal responses

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