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While it becomes thus clear that several nutrients exert modulatory effects on (neuro)inflammatory processes, the specific pathway via which they exert these effects remains to be understood and are most likely a combination of direct and indirect processes potentially involving for example the gut microbiome [166] and the hypothalamus-pituitary-adrenal (HPA)-axis [190]

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once a day for 6 consecutive days before induction of ischemia and at the beginning of reperfusion) significantly reduces the serum alanine aminotransferase (ALT) level in rats with ischemia-reperfusion model [6]