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Tan S, Ignatenko S, Wagner F, Dokras A, Seufert J, Zwanziger D, Dunschen K, Zakaria M, Huseinovic N, Basson CT, Mahling P, Fuhrer D, Hinder M

Unlike normal blood vessels, tumor vasculature displays multiple functional and structural abnormalities characterized by unusual leakiness, high tortuosity, and poor coverage by pericytes (Tahergorabi and Khazaei, 2012), the maturity and stability of blood vessels are being increasingly recognized in the assessment of tumor vasculature (Tellier et al., 2015)

This creates a bluish or purple tint that we recognize as dark circles

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