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GDNF growth factors BBB blood- brain barrier permeability the invention provides small molecule mimetics (mimic) of the growth factor "hepatocyte growth factor (HGF) that are orally active, display profound growth factor activity, and are inexpensive to synthesize

The proactive arm governs proteome production and maturation, translation, co-translational quality control, chaperone-assisted folding, trafficking, and compartment-specific targeting, thereby limiting the generation of metastable or mislocalized proteins (Fig