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Wine presents specific considerations on retatrutide: Acidity increases GI symptoms: Wines acidity amplifies reflux and nausea more than spirits or beer Serving sizes are deceptive: Restaurant wine pours often exceed standard drink definitions (5 oz) Sulfites may worsen headaches: The enhanced intoxication combined with sulfite sensitivity creates more pronounced headaches Red wine seems better tolerated: Anecdotal reports suggest red wine causes less acute GI distress than white, possibly due to lower acidity If you choose wine on retatrutide, measure pours at home (use a 5 oz marking on wine glasses) and request half-glasses at restaurants to maintain control over actual alcohol consumption