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[117] studied the use of IN OT in children with PraderWilli Syndrome (PWS)

But prolonged vitamin B12 deficiency can also cause it

Cloudiness can indicate denaturation, aggregation, contamination, or compromise of the lyophilized starting material

A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)