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How They Work: Central and Peripheral Effects The effects of GLP-1 receptor agonists operate on two levels simultaneously, and understanding both is important for appreciating why they are relevant to the menopausal metabolic transition described in the previous section

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In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]